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Hexapeptide-11 The Ultimate Peptide for Smoothing & Plumping

Products Name Hexapeptide-11
CAS No 161258-30-6
INCI Name Hexapeptide-11
Specification ≥98% (HPLC)
Molecular Weight 689.8 g/mol
Chemical Formula C₃₁H₅₂N₈O₈
Appearance White to off-white powder
Solubility Soluble in water
    calcium-lactate-(16)
    01

    Product Description

    1. Mechanism of Action 
    Hexapeptide-11 is a synthetic bioactive peptide specifically designed to target the visible signs of aging, particularly sagging skin and loss of facial contour. Its primary mechanism of action is dual-focused:
    Collagen Boosting: It upregulates the synthesis of key structural proteins in the dermis, including Collagen Types I, III, and IV, as well as Laminin. This enhances the density and integrity of the extracellular matrix, leading to firmer, more resilient skin.

    Focal Adhesion Reinforcement: The peptide strengthens the connection between the dermis and the epidermis by promoting the assembly of Focal Adhesion complexes. This provides a "lifting" effect, improving skin tightness and reducing the appearance of sagging.

    2. In Vitro Efficacy Data 
    Human Fibroblast Culture Studies:
    +58% increase in Collagen I synthesis.
    +35% increase in Collagen IV synthesis.
    +52% increase in Laminin synthesis.
    Significant enhancement in the formation of focal adhesion plaques, observed via immunofluorescence staining.

    3. Clinical Results 
    Study Design: In-vivo clinical study on female volunteers (aged 45-60) with a 2% concentration of Hexapeptide-11, applied twice daily for 56 days. Results were measured via instrumental analysis and expert grading.

    Key Findings:
    -15% in sagging (cheek ptosis) as measured by facial imaging software.
    +18% improvement in skin firmness, as measured by cutometry.
    -21% in the depth of nasolabial folds, as assessed by expert grading.
    Significant improvement in overall facial contour and definition.

     Safety & Compatibility

    Thickeners

    Safety

    Hexapeptide-11 is a synthetic peptide with a high safety profile. It is non-irritating and non-sensitizing in standard safety assessments. It is suitable for use in formulations for sensitive skin.
    Actives

    Compatibility

    Highly compatible with a wide range of cosmetic ingredients, including other peptides, vitamins, and hyaluronic acid. Stable in aqueous solutions within a pH range of 4.0 - 7.0. Can be effectively incorporated into various emulsions, serums, gels, and patches.
    calcium-lactate-(16)
    01

     Recommended Usage & Formulation 

    Recommended Concentration: 1% - 3%

    Ideal For Use In:
    Firming & Lifting Serums
    Anti-Aging & Wrinkle Creams
    Eye Contour Treatments
    Neck Firming Products
    Sheet Masks & Ampoules

    Summary & Key Selling Points

    Applications1
    01

    Clinically Proven Lifting Effect

    Significantly reduces sagging and improves facial contour.
    Applications3
    01

    Multi-Targeted Action

    Boosts multiple types of collagen and reinforces dermal-epidermal adhesion.
    Applications5
    03

    Visible Firming

    Improves skin firmness and elasticity.
    Applications5
    03

    High Safety & Compatibility

    Ideal for a wide range of cosmetic formulations, including those for sensitive skin.
    storage

    Storage

    Store in a closed container at a dry place at room temperature.

    gmo1

    Animal Testing

    Not animal tested

    vegetarian1

    Vegan

    Does not contain animal-derived components

    gmo

    GMO

    No data available

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